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        木糖醇(Xylitol)-藥用料手冊(第六版)中英文對照

        lyhkprc  2021-04-13 23:55  570  1
        lyhkprc

        木糖醇(Xylitol)-藥用料手冊(第六版)中英文對照

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        • lyhkprc
          lyhkprc2021-04-13 23:55
          沙發
          Nonproprietary  Names Xylitol
          page786
          通用名木糖醇
          Alkalizing  agent.Coating  agent; diluent; emollient; humectant; sweetening agent;
              tablet and capsule diluent; tablet filler.
          功能類別包衣劑;稀釋劑;潤膚劑;保濕劑;甜味劑;片劑和膠囊稀釋劑;片劑填充劑。
             
          Applications  in Pharmaceutical Formulation or Technology Xylitol  is used as a noncariogenic sweetening agent in a variety of pharmaceutical  dosage forms, including tablets, syrups, and coatings. It is also widely used  as an alternative to sucrose in foods and as a base for medicated  confectionery. Xylitol is finding increasing application in chewing gum,(1,2)  mouthrinses,(3) and toothpastes(4) as an agent that decreases dental plaque  and tooth decay (dental caries). Unlike sucrose, xylitol is not fermented  into cariogenic acid end products(5) and it has been shown to reduce dental  caries by inhibiting the growth of cariogenic Streptococcus mutans  bacteria.(6,7) As xylitol has an equal sweetness intensity to sucrose,  combined with a distinct cooling effect upon dissolution of the crystal, it  is highly effective in enhancing the flavor of tablets and syrups and masking  the unpleasant or bitter flavors associated with some pharmaceutical actives  and excipients.
              In topical cosmetic and toiletry applications, xylitol is used primarily  for its humectant and emollient properties, although it has also been  reported to enhance product stability through a combination of potentiation  of preservatives and its own bacteriostatic and bactericidal properties.  Granulates of xylitol are used as diluents in tablet formulations,where they  can provide chewable tablets with a desirable sweet taste and cooling  sensation, without the ‘chalky’ texture experienced with some other tablet  diluents. Xylitol solutions are employed in tablet-coating applications at  concentrations in excess of 65% w/w Xylitol coatings are stable and provide a  sweet-tasting and durable hard coating.
              In liquid preparations, xylitol is used as a sweetening agent and vehicle  for sugar-free formulations. In syrups, it has a reduced tendency to  ‘cap-lock’ by effectively preventing crystallization around the closures of  bottles. Xylitol also has a lower water activity and a higher osmotic  pressure than sucrose, therefore enhancing product stability and freshness.  In addition, xylitol has also been demonstrated to exert certain specific  bacteriostatic and bactericidal effects, particularly against common spoilage  organisms.(8,9)
              Therapeutically, xylitol is additionally utilized as an energy source for  intravenous infusion therapy following trauma.(10)
          在藥物配方或技術中的應用木糖醇用作各種藥物劑型中的非致癌甜味劑,包括片劑,糖漿和包衣。它也被廣泛用作食品中蔗糖的替代品和藥物糖果的基礎。木糖醇作為減少牙菌斑和蛀牙(齲齒)的藥劑在口香糖,(1,2)漱口劑,(3)和牙膏(4)中的應用越來越多。與蔗糖不同,木糖醇不會發酵成致齲酸終產物(5),并且已經顯示通過抑制致齲變形鏈球菌細菌的生長來減少齲齒。(6,7)由于木糖醇具有與蔗糖相同的甜度強度,結合在晶體溶解時具有明顯的冷卻作用,它在增強片劑和糖漿的味道以及掩蓋與一些藥物活性劑和賦形劑相關的不愉快或苦味方面非常有效。
              在局部化妝品和化妝品應用中,木糖醇主要用于其保濕劑和潤膚劑性質,盡管據報道通過增強防腐劑及其自身的抑菌和殺菌性質的組合來增強產品穩定性。木糖醇顆粒用作片劑配方中的稀釋劑,其中它們可以提供具有所需甜味和清涼感的咀嚼片劑,而沒有其他片劑稀釋劑所經歷的“白堊”質地。木糖醇溶液以超過65%w/w的濃度用于片劑包衣應用木糖醇包衣是穩定的并且提供甜味和耐用的硬包衣。
              在液體制劑中,木糖醇用作無糖制劑的甜味劑和載體。在糖漿中,通過有效防止瓶子閉合周圍的結晶,它減少了“封蓋”的趨勢。木糖醇還具有比蔗糖更低的水分活度和更高的滲透壓,因此增強了產品的穩定性和新鮮度。此外,木糖醇還被證明具有一定的抑菌和殺菌作用,特別是對常見的腐敗生物。(8,9)
              在治療上,木糖醇還被用作創傷后靜脈輸注治療的能量來源。(10)
          DescriptionXylitol  occurs as a white, granular solid comprising crystalline,equidimensional  particles having a mean diameter of about 0.4–0.6 mm. It is odorless, with a  sweet taste that imparts a cooling sensation. Xylitol is also commercially  available in powdered form,and several granular, directly compressible  forms.(11) See also Section 17.
          描述木糖醇為白色、結晶性顆粒狀固體,其各方向有相等的粒徑,約為0.4~0.6mm。木糖醇無臭,但具有清涼感的甜味??捎糜诠I生產的木糖醇有粉末狀和數種顆粒狀,可供直接壓片(11)。另見第17項。

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